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THE BINDING OF TRIETHYLTIN TO RAT BRAIN MYELIN
Author(s) -
Lock E. A.,
Aldridge W. N.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb04420.x
Subject(s) - chemistry , myelin , binding site , biochemistry , central nervous system , medicine
—A high affinity binding site for triethyltin was found in rat brain myelin with an affinity of approx 6·6 × 10 5 m −1 at pH 7·5. Competitive binding studies showed that triethyl‐lcad had about the same affinity and trimethyltin 30 times lower affinity than triethyltin. Hexachlorophane and 3,5‐diiodo‐4′‐chlorosalicylanilide did not prevent triethyltin binding to rat brain myelin. Since triethyltin, hexachlorophane and 3,5‐diiodo‐4′‐chlorosalicylanilide all produce similar oedematous lesions in the brain of rats, whereas triethyl‐lead and trimethyltin do not, it is concluded that the high affinity triethyltin binding site either is not involved or is not the only factor in oedema production.