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STRIATAL METABOLISM OF DOPAMINE IN MICE MADE AGGRESSIVE BY ISOLATION
Author(s) -
Hutchins D. A.,
Pearson J. D. M.,
Sharman D. F.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb03891.x
Subject(s) - dopamine , dopaminergic , metabolite , 3,4 dihydroxyphenylacetic acid , striatum , reuptake , homovanillic acid , metabolism , medicine , endocrinology , chemistry , pharmacology , biology , serotonin , receptor
Abstract— Male albino mice were made aggressive by isolation. When such mice were exposed to a second mouse or placed in a fresh environment there was an increase in the concentration of 3,4‐dihydroxyphenylacetic acid, a metabolite of dopamine, in the striatum. The possibility that this might reflect an alteration in the reuptake of dopamine into dopaminergic neurons in this tissue is considered.