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ACETYL‐COENZYME A: 1,4‐DIAMINOBUTANE N ‐ACETYLTRANSFERASE: ACTIVITY IN RAT BRAIN DURING DEVELOPMENT, IN EXPERIMENTAL BRAIN TUMOURS AND IN BRAINS OF FISH OF DIFFERENT METABOLIC ACTIVITY
Author(s) -
Seiler N.,
Lamberty Ursula,
AlTherib M. J.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb03867.x
Subject(s) - fish <actinopterygii> , metabolic activity , biology , biochemistry , chemistry , physiology , fishery
—Acetyl‐CoA: 1,4‐diaminobutane N ‐acetyltransferase catalyses the first step of putrescine catabolism in mammalian brain. It may be important in putrescine degradation of other tissues as well. Its specific activity is higher in homogenates of immature than of mature rat brains. A steady decline of putrescine acetylase activity is observed from birth until approx adult levels are reached at day 30. Microsomes and purified nuclei from brains of 2‐day‐old rats show considerably higher putrescine acetylase activities than the corresponding subcellular organelles from adult brains. Increased putrescine acetylase activities were found in nitroso‐ethylurea‐induced gliomas, together with a dramatic increase of putrescine concentration. High tissue concentrations of putrescine are, however, not necessarily correlated with enhanced putrescine acetylase activities. In trout brains a linear increase of acetyl‐CoA: 1,4‐diaminobutane N ‐acetyltransferase activity was observed together with a decrease of putrescine concentration after adaptation of the animals to increased water temperature.