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EARLY CHANGES IN ACETYLCHOLINE POOLS IN THE HIPPOCAMPUS OF THE RAT BRAIN AFTER SEPTAL LESIONS
Author(s) -
Potempska Anna,
Grądkowska Malgorzata,
OderfeldNowak Barbara
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb03865.x
Subject(s) - acetylcholine , choline acetyltransferase , hippocampus , acetylcholinesterase , choline , chemistry , medicine , endocrinology , cholinergic , neuroscience , biology , biochemistry , enzyme
—After placement of lesions in the hippocampus by electrocoagulation, an increase in bound acetylcholine above control levels was shown. There was no concomitant rise in free acetylcholine. The rise in bound acetylcholine was not due to changes in levels of either acetylcholinesterase or choline acetyltransferase and it is suggested that the interruption of septal impulses and/or alterations in uptake or availability of substrates is responsible.