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CHOLINE ACETYLTRANSFERASE AND CHOLINESTERASE IN SKELETAL MUSCLE REGENERATION
Author(s) -
Max S. R.,
Rifenberick D. H.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb03862.x
Subject(s) - choline acetyltransferase , cholinesterase , regeneration (biology) , skeletal muscle , choline , acetylcholinesterase , microbiology and biotechnology , biochemistry , chemistry , anatomy , cholinergic , neuroscience , biology , endocrinology , enzyme
—The activities of choline acetyltransferase and cholinesterase have been measured in homogenates of rat anterior tibial muscles following intramuscular injection of the myotoxic agent Marcaine (plus hyaluronidase). Marcaine causes rapid degeneration of skeletal muscle followed by complete regeneration. By the first day after administration of Marcaine the activities of both enzymes decreased markedly. The activities then increased concomitantly with regeneration of drug‐treated muscles. Choline acetyltransferase attained the control level by the 19th day following Marcaine treatment. Cholinesterase activity became greater than the control value by the seventh day and decreased to control activity by the 19th day following injection of Marcaine. The results are discussed in terms of the relationship between nerve and muscle during Marcaine induced degeneration and regeneration.