Premium
PLASMA CHOLINE: ITS TURNOVER AND EXCHANGE WITH BRAIN CHOLINE 1
Author(s) -
Freeman J. J.,
Choi R. L.,
Jenden D. J.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb03856.x
Subject(s) - choline , chemistry , medicine , venous blood , endocrinology , kinetics , blood plasma , plasma , compartment (ship) , turnover , distribution (mathematics) , plasma concentration , plasma levels , biochemistry , mathematical analysis , physics , oceanography , mathematics , management , quantum mechanics , economics , geology
—The kinetics of plasma choline (Ch) and the uptake of plasma Ch into the brain were studied by means of intravenous infusion of [ 2 H 4 ]Ch at various rates into anaesthetized and conscious rats. [ 2 H 4 ]Ch levels in both arterial and venous plasma at steady state were linearly related to the infusion rate; however, unlabelled Ch levels were independent of infusion rate. [ 2 H 4 ]Ch levels were higher in the arterial plasma than in the venous plasma, while unlabelled Ch levels were higher in the venous plasma than in the arterial plasma. It was concluded that Ch is being generated in the brain and is released into the venous effluent. The supply of Ch to the plasma is not decreased if the plasma Ch level is increased. The clearance and turnover of Ch in the compartment of its initial distribution are 75 ml kg ‐1 min ‐1 and 716 nmol kg ‐1 min ‐1 , respectively. The uptake of plasma Ch into the brain is not saturated even at very high levels of plasma Ch.