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SELECTIVE INCREASE OF BRAIN DOPAMINE SYNTHESIS BY SULPIRIDE
Author(s) -
Tagliamonte A.,
Montis G. de,
Olianas M.,
Vargiu L.,
Corsini G. U.,
Gessa G. L.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb03852.x
Subject(s) - sulpiride , dopamine , neuroscience , chemistry , psychology , dopaminergic
—Sulpiride (5–200 mg/kg) increases brain HVA and DOPAC levels, causes no change in dopamine concentration, does not interfere with the outflow of HVA from the CNS and enhances the disappearance of brain dopamine after inhibition of tyrosine hydroxylase. The compound influences neither 5‐HT nor NE metabolism. The central action of sulpiride differs from that of classic neuroleptics in that this drug stimulates dopamine turnover without producing catalepsy.