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THE PROPORTIONATE LOSS OF l ‐3,4‐DIHYDROXYPHENYLALANINE AND l ‐5‐HYDROXYTRYPTOPHAN DECARBOXYLATING ACTIVITY IN RAT CENTRAL NERVOUS SYSTEM FOLLOWING INTRACISTERNAL ADMINISTRATION OF 5,6‐DIHYDROXYTRYPTAMINE OR 6‐HYDROXYDOPAMINE
Author(s) -
Dairman W.,
Horst W. Dale,
Marchelle Mary E.,
Bautz G.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb03837.x
Subject(s) - serotonin , hydroxydopamine , 5,7 dihydroxytryptamine , medicine , endocrinology , 5 hydroxytryptophan , catecholamine , dihydroxyphenylalanine , central nervous system , biology , dopamine , serotonergic , dopaminergic , receptor
—5,6‐Dihydroxytryptamine or 6‐hydroxydopamine was administered intracisternally to rats to effect a selective destruction of serotonin or catecholamine‐containing neurons. The l ‐DOPA and l ‐5‐hydroxytryptophan decarboxylating activities of the spinal cord and brain were then determined at several time intervals following this treatment. In both cases the relative loss of l ‐DOPA decarboxylating activity was the same as the relative loss of l ‐5‐hydroxytryptophan decarboxylating activity. 5,6‐Dihydroxytryptamine treatment had little or no effect on catecholamine‐containing neurons and 6‐hydroxydopamine did not effect serotonin‐containing neurons. These data support the idea that only one decarboxylase is involved in the biosynthesis of both serotonin and catecholamines in the rat CNS.