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EFFECTS OF NEONATAL PANTOTHENIC ACID DEFICIENCY ON BRAIN LIPID COMPOSITION IN RATS 1
Author(s) -
Rajalakshmi R.,
Nakhasi H. L.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb03665.x
Subject(s) - pantothenic acid , endocrinology , medicine , litter , biology , phospholipid , cholesterol , galactolipid , biochemistry , vitamin , membrane , agronomy
—Studies were made of the effects of pantothenic acid deficiency during the neonatal period on brain lipids in rats. Mothers with 6–8 pups to a litter were fed from soon after birth a diet either normal or deficient in pantothenate. An additional control group (restricted controls) was pair‐fed with the deficient group. Significant deficits were found in the pups of the pantothenate‐deficient group and in those of the restricted controls with regard to body weight, brain weight and brain concentration of lipids (total lipid, cholesterol, phospholipid, galactolipid and gangliosides) at 21 days of age. The deficits in both these groups were comparable. The results suggest that the effects of pantothenate deficiency may be due to the resulting growth deficit rather than to the deficiency of pantothenate per se .