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INHIBITION BY APOMORPHINE OF DOPAMINE DEAMINATION IN THE RAT BRAIN
Author(s) -
Chiara G. Di,
Balakleevsky A.,
Porceddu M. L.,
Tagliamonte A.,
Gessa G. L.
Publication year - 1974
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1974.tb12205.x
Subject(s) - homovanillic acid , apomorphine , reserpine , dopamine , deamination , monoamine oxidase , pargyline , medicine , endocrinology , chemistry , iproniazid , 3,4 dihydroxyphenylacetic acid , catechol o methyl transferase , dopaminergic , serotonin , biochemistry , biology , enzyme , receptor , allele , gene
— Apomorphine (A) inhibited dopamine deamination by rat brain mitochondria, but did not influence catechol‐ O ‐methyltransferase (COMT) activity by brain homogenates. The administration of apomorphine (10mg/kg i.p.) to normal rats increased brain dopamine (DA) by 34 per cent and decreased homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) by 60 per cent. In rats treated with reserpine 15 min prior to A, the latter prevented the rise of cerebral HVA and DOPAC and the depletion of DA produced by the former. Finally, A decreased the L‐DOPA‐induced accumulation of HVA and DOPAC in the rat basal ganglia. These results indicate that A inhibits DA deamination by monoamine oxidase. This inhibition seems to be specific since apomorphine did not influence 5‐HIAA levels in normal rats and prevented neither central 5‐HT depletion nor 5‐HIAA rise induced by reserpine.