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METAL CHELATES IN THE STORAGE AND TRANSPORT OF NEUROTRANSMITTERS: INTERACTIONS OF Cu 2+ WITH ATP AND BIOGENIC AMINES 1, 2
Author(s) -
Rajan K. S.,
Davis J. M.,
Colburn R. W.
Publication year - 1974
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1974.tb12190.x
Subject(s) - chemistry , chelation , affinities , metal , amine gas treating , catechol , ternary complex , copper , inorganic chemistry , moiety , metal ions in aqueous solution , ternary operation , stereochemistry , organic chemistry , enzyme , programming language , computer science
— The thermodynamic stabilities of the coordinate binding of Cu 2+ ion with adenosinetriphos‐phate (ATP) and several biogenic amines have been determined in aqueous model systems in an attempt to examine the possible correlation between metal‐amine binding and the in vivo affinities of the amines for granule‐binding. In each of the ternary chelate systems consisting of Cu 2+ ‐ATP‐amine (1:1:1), the Cu 2+ ion is preferentially bound by ATP in the pH range 3–5 with a stability constant of Log K ML = 517. In the pH range 5–8 each of the biogenic amines coordinates with Cu 2+ ‐ATP chelate to form the respective ternary chelate. The nature and strength of binding of fourteen different amines with Cu 2+ ‐ATP have been evaluated on the basis of the stabilities of the ternary chelates. On the basis of the quantitative equilibrium data generated in this study, it appears that both pyrocatechol moiety and the ethanolamine side‐chain of the catechol amines are involved in the coordination of copper. The metal‐binding stabilities of the biogenic amines are then correlated with the molecular structure, donor basicities and the in vivo affinities of the amines for granule‐binding in order to rationalize the possible involvement of metal chelates in the monoamine binding, storage and transport.