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INHIBITION OF THE BIOCHEMICAL AND MORPHOLOGICAL MATURATION OF ADRENERGIC NEURONS BY NICOTINIC RECEPTOR BLOCKADE
Author(s) -
Black I. B.,
Geen S. C.
Publication year - 1974
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1974.tb11594.x
Subject(s) - chlorisondamine , blockade , muscarinic acetylcholine receptor , ganglionic blocker , tyrosine hydroxylase , nicotinic agonist , ganglion type nicotinic receptor , endocrinology , superior cervical ganglion , medicine , atropine , chemistry , ganglion , pharmacology , receptor , hexamethonium , nicotinic acetylcholine receptor , biology , neuroscience , dopamine , blood pressure
— The developmental increases of tyrosine hydroxylase, dopa decarboxylase and doparnine‐β‐hydroxylase activities in neonatal mouse superior cervical ganglion were prevented by administration of the ganglionic blocking agent chlorisondamine. In addition, ganglionic blockade prevented the normal post‐natal increase in ganglion volume and neuron numbers. Inhibition of development followed nicotinic‐receptor blockade, but not muscarinic blockade with atropine.