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EFFECT OF l ‐DOPA ON BRAIN CONCENTRATION OF DOPAMINE AND HOMOVANILLIC ACID IN RATS AFTER CHRONIC MANGANESE CHLORIDE ADMINISTRATION
Author(s) -
Bonilla E.,
DiezEwald María
Publication year - 1974
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1974.tb11593.x
Subject(s) - homovanillic acid , dopamine , endocrinology , medicine , tyrosine hydroxylase , chemistry , catecholamine , manganese , tyrosine , dopaminergic , metabolism , biochemistry , serotonin , receptor , organic chemistry
— Rats chronically treated with a high oral load of MnCl 2 showed decreased concentrations of dopamine and HVA in brain. A return to normal values was observed after l ‐DOPA injections. This suggests a disturbance in catecholamine metabolism after chronic manganese administration possibly at the level of l ‐tyrosine hydroxylase.