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BRAIN ACETYLCHOLINE AND CHOLINESTERASE: EFFECT OF PHENOTHIAZINES AND PHYSOSTIGMINE INTERACTION IN RATS 1
Author(s) -
Sethy V. H.,
Van Woert M. H.
Publication year - 1974
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1974.tb06922.x
Subject(s) - physostigmine , acetylcholine , cholinesterase , thioridazine , chlorpromazine , chemistry , pharmacology , long term potentiation , blockade , receptor , biochemistry , medicine
— The effect of phenothiazines either alone or in combination with physostigmine on whole brain acetylcholine concn and cholinesterase activity has been investigated in male rats. Phenothiazines (chlorpromazine, trifluperazine and thioridazine) when injected alone had no significant effect on brain acetylcholine concentration. Pretreatment with chlorpromazine and thioridazine significantly enhanced the physostigmine‐induced increase in brain acetylcholine concn and inhibition of cholinesterase activity. However, trifluperazine had no significant effect on the physostigmine‐induced increase in brain acetylcholine concentration and inhibition of cholinesterase activity. The potentiation of the physostigmine‐induced increase in brain acetylcholine concn by phenothiazines may be due to (1) increased acetylcholine turnover secondary to the blockade of dopamine receptors by neuroleptic drugs and.