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INCREASED CONCENTRATIONS OF ACIDIC METABOLITES OF DOPAMINE IN THE SUPERIOR CERVICAL GANGLION FOLLOWING PREGANGLIONIC STIMULATION IN VIVO
Author(s) -
Pearson J. D. M.,
Sharman D. F.
Publication year - 1974
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1974.tb06892.x
Subject(s) - homovanillic acid , dopamine , superior cervical ganglion , stimulation , cervical ganglia , ganglion , 3,4 dihydroxyphenylacetic acid , endocrinology , medicine , in vivo , chemistry , sympathetic ganglion , biology , anatomy , serotonin , receptor , microbiology and biotechnology
—Evidence is presented for the presence of two acidic metabolites of dopamine, 3,4‐dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the sympathetic ganglia of some mammalian species other than ruminants. In the pig, electrical stimulation of the preganglionic nerves to the superior cervical ganglion results in a mean increase of 78 per cent in the concentration of HVA and a mean increase of 372 per cent in the concentration of DOPAC in this sympathetic ganglion. These results can be interpreted as further evidence for the involvement of dopamine in transmission at sympathetic ganglia.