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CTP SYNTHETASE ACTIVITY IN NEONATAL AND ADULT RAT BRAIN
Author(s) -
Genchev D. D.,
Mandel P.
Publication year - 1974
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1974.tb04332.x
Subject(s) - enzyme , cerebellum , dna ligase , biochemistry , enzyme assay , nucleotide , biosynthesis , cytidine , specific activity , biology , chemistry , endocrinology , gene
—The activity of CTP synthetase (UTP:ammonia ligase (ADP‐forming), EC 6.3.4.2) in adult and new‐born rat brain was determined by an enzyme assay using [ 14 C]UTP as a substrate. The activity was age‐dependent and showed a distinctive distribution pattern between the cerebral hemispheres and cerebellum. The possible correlations between the activity of CTP synthetase and the rate of RNA or lipid biosynthesis, as well as the regulatory importance of the enzyme in the formation of cytidine nucleotides are discussed.