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INHIBITION OF THE BIOSYNTHESIS OF ISOPRENOID COMPOUNDS BY PHENOLIC ACIDS IN THE RAT BRAIN
Author(s) -
Ranganathan S.,
Ramasarma T.
Publication year - 1974
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1974.tb04326.x
Subject(s) - phenylalanine , tyrosine , biochemistry , metabolism , biosynthesis , mevalonic acid , sterol , chemistry , terpenoid , inhibitory postsynaptic potential , amino acid , biology , cholesterol , enzyme , endocrinology
—The incorporation of [2‐ 14 C]mevalonate into nonsaponifiable lipids by rat brain homogenates is inhibited by phenolic acids derived from tyrosine. The phenyl acids derived from phenylalanine are inhibitory only at very high concentrations compared with phenolic acids. The brain is more sensitive to inhibition by the phenolic acids than the liver. These studies indicate a possible role for phenolic acids in the impairment of cerebral sterol metabolism in phenylketonuria.