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TRANSPORT OF PROTEINS, GLYCOPROTEINS AND CHOLINERGIC ENZYMES IN REGENERATING HYPOGLOSSAL NEURONS 1
Author(s) -
Frizell M.,
Sjöstrand J.
Publication year - 1974
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1974.tb04303.x
Subject(s) - acetylcholinesterase , axoplasmic transport , fucose , biochemistry , hypoglossal nerve , glycoprotein , regeneration (biology) , chemistry , choline acetyltransferase , cerebellum , cholinergic , biology , medicine , microbiology and biotechnology , endocrinology , enzyme , tongue , linguistics , philosophy
The accumulation of [ 3 H]leucine‐ and [ 3 H]fucose‐labelled axonal proteins, acetyl‐CoA : choline O ‐acetyltransferase (ChAc, EC 2.3.1.6) and acetylcholinesterase (AChE, EC 3.1.1.7) was studied proximal to a ligature applied to the hypoglossal nerve of the rabbit at different phases of nerve regeneration. After 1 week of regeneration, the accumulation of rapidly migrating [ 3 H]leucine‐labelled proteins, ChAc and AChE was reduced as compared to that of the contralateral nerve. In contrast, the accumulation of [ 3 H]fucose‐labelled glycoproteins was markedly increased. After a regeneration period of 4‐6 weeks, the accumulation of proteins and glycoproteins in the regenerating nerve was increased whereas the accumulation of ChAc and AChE was almost normal. The results indicate an initial depression of the synthesis and axonal transport of the bulk of rapidly migrating proteins, ChAc and AChE in the chromatolytic hypoglossal neurons whereas the synthesis and transport of rapidly migrating glycoproteins is increased. These initial changes are less pronounced during the subsequent regeneration period.