Premium
5‐HYDROXYTRYPTAMINE AND NORADRENALINE IN THE HIPPOCAMPAL REGION: EFFECT OF TRANSECTION OF AFFERENT PATHWAYS ON ENDOGENOUS LEVELS, HIGH AFFINITY UPTAKE AND SOME TRANSMITTER‐RELATED ENZYMES
Author(s) -
StormMathisen J.,
Guldberg H. C.
Publication year - 1974
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1974.tb04297.x
Subject(s) - monoaminergic , hippocampal formation , chemistry , medicine , neuroscience , endocrinology , anatomy , serotonin , biochemistry , biology , receptor
The monoaminergic fibres enter the hippocampal formation through a dorsal and a ventral route. The dorsal route consisting of fimbria, fornix superior and cingulum, was estimated to supply about 75% of the 5‐HT fibres and 40% of the noradrenaline containing (NA) fibres. The ventral route, allegedly passing through the amygdaloid area, accounts for the rest. The cingulum bundle contributes a definite part of the 5‐HT fibres but very few of the NA fibres. No evidence was found for an intrinsic origin of monoaminergic fibres in the hippocampal region. Monoamine oxidase and catechol‐ O ‐methyltransferase showed no change following the lesions and are considered to be localized predominantly outside the aminergic neurones. The results on DOPA decarboxylase indicate that about 50% of the enzyme is situated outside 5‐HT and NA nerves. Glutamic acid decarboxylase did not decrease even after transection of the ventral route, substantiating the earlier conclusion that this enzyme is situated in intrinsic neurones in the hippocampal region. For choline acetyltransferase and AChE the dorsal route was confirmed to be the only quantitatively important way of access. None of the enzymes studied, nor the uptake activities, were affected by cervical sympathectomy.