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CARBOHYDRATE METABOLISM IN BRAIN DURING CONVULSIONS AND ITS MODIFICATION BY PHENOBARBITONE 1
Author(s) -
King Lucy J.,
Carl Juanita L.,
Lao Lauro
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb12146.x
Subject(s) - glycolysis , citric acid cycle , metabolism , carbohydrate metabolism , stimulation , chemistry , oxidative phosphorylation , citric acid , anaerobic exercise , anticonvulsant , pyruvic acid , endocrinology , medicine , biochemistry , biology , epilepsy , physiology , neuroscience
— Assays of citric acid cycle substrates and metabolites of the second stage of the glycolytic pathway have completed a series of studies of glucose metabolism in brains of mice rapidly frozen at intervals during electrically‐induced, tonic‐clonic convulsions. Citric acid cycle metabolism reached a new equilibrium at a significantly higher rate. However, oxidative metabolism did not keep up with the demand for energy supplies, as indicated by an increasing lactate level and an increasing lactate: pyruvate ratio. Administration of a sub‐anaesthetic but anticonvulsant dose of phenobarbitone prior to convulsive electrical stirnulation was associated with as great an increase in anaerobic glycolysis as in mice given no drug prior to stimulation; but oxidative metabolism was not enhanced, as reflected by even greater lactate: pyruvate ratios in mice given phenobarbitone than in mice given no drug prior to convulsive stimulation.