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GABA UPTAKE IN RAT BRAIN SLICES: INHIBITION BY GABA ANALOGUES AND BY VARIOUS DRUGS
Author(s) -
Beart P. M.,
Johnston G. A. R.
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb12131.x
Subject(s) - chemistry , pharmacology , non competitive inhibition , gabaa receptor , gaba receptor antagonist , biochemistry , neuroscience , biology , bicuculline , receptor , enzyme
— 2‐Hydroxy‐, 2‐chloro‐, 2‐ and Cmethyl‐GABA are linear competitive inhibitors of GABA uptake in rat brain slices. These analogues are thus potential substrates for the GABA transport system and possible‘false transmitters'. 2‐Hydroxy‐GABA is the most potent inhibitor of GABA uptake yet described. No specific inhibitor of GABA uptake was revealed amongst the drugs tested.