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ADENOSINE 3′,5′‐MONOPHOSPHATE IN GUINEA PIG CEREBRAL CORTICAL SLICES: EFFECTS OF α‐ AND β‐ADRENERGIC AGENTS, HISTAMINE, SEROTONIN AND ADENOSINE
Author(s) -
Schultz J.,
Daly J. W.
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb06002.x
Subject(s) - phenoxybenzamine , adenosine , phentolamine , methysergide , histamine , medicine , endocrinology , propranolol , norepinephrine , serotonin , chemistry , adrenergic , guinea pig , adenosine a1 receptor , adrenergic receptor , pharmacology , adenosine receptor , receptor , agonist , dopamine
—Norepinephrine and epinephrine, in combination with either adenosine or histamine, enhanced the accumulation of cyclic AMP in guinea pig cerebral cortical slices. Isoproterenol had only marginal effects under the same conditions. Studies with d ‐ and l ‐norepinephrine and with the α‐ and β‐adrenergic blocking agents, phenoxybenzamine, phentolamine, dihydroergokryptamine, propranolol and sotalol, indicated that the effect of catecholamines on cyclic AMP levels in this tissue was stereo‐specific and was mediated primarily via interaction with a classical α‐adrenergic receptor. Studies with the antihistaminics, diphenhydramine and pheniramine, and the antiserotonin agent, methysergide, indicated that guinea pig cerebral cortical slices contain receptors for histamine and serotonin, whose activation also stimulates an enhanced accumulation of cyclic AMP in the presence of adenosine.