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THE BIOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF 6‐AMINODOPAMINE: SIMILARITY WITH 6‐HYDROXYDOPAMINE
Author(s) -
Heikkila R. E.,
Mytilineou Catherine,
Cote L. J.,
Cohen G.
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb04230.x
Subject(s) - hydroxydopamine , similarity (geometry) , neuroscience , chemistry , biology , computer science , artificial intelligence , dopamine , dopaminergic , image (mathematics)
6‐aminodopamine was injected intraperitoneally into male Swiss–Webster mice. At 72 h post injection 6‐aminodopamine had caused a reduction in the endogenous content of heart norepinephrine, a decrease in the capacity of heart slices to accumulate [ 3 H]‐norepinephrine in vitro , and a virtual disappearance of the adrenergic plexus of the mouse iris as viewed by fluorescence histochemistry. Similar data were obtained with the same dose of 6‐hydroxydopamine. These data suggest that 6‐aminodopamine causes a destruction of sympathetic nerve terminals. Model experiments showed that 6‐aminodopamine, like 6‐hydroxydopamine, generated H 2 o 2 both in vitro and in vivo . 6‐Aminodopamine, like 6‐hydroxydopamine, also blocked the accumulation of [ 3 H]dopamine into slices of rat brain in vitro .