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THE RELATIONSHIP BETWEEN DNA SYNTHESIS AND NUCLEAR PROTEINS IN THE CEREBRUM AND CEREBELLUM OF 8‐DAY‐OLD RATS
Author(s) -
Burdman J. A.,
Szijan I.,
Franzoni L.,
Argiz C. A. Garcia
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb00287.x
Subject(s) - cerebrum , cerebellum , biology , dna , rna , biochemistry , leucine , medicine , endocrinology , microbiology and biotechnology , chemistry , amino acid , gene , central nervous system
In‐8‐day‐old rats the higher rate of DNA replication in cerebellum than in cerebrum is accompanied by an enhanced synthesis of nuclear proteins. The greatest difference between the incorporation of tritiated leucine into proteins of cerebral and cerebellar cell nuclei occurs in the acid‐soluble deoxyribonucleoproteins. However, the specific radioactivity of the acidic deoxyribonucleoproteins is similar in both tissues. The relative content of these proteins and the activity of the RNA polymerase is higher in cerebrum than in cerebellum. The results suggest that in the cerebrum of young rats these proteins are mainly concerned with the regulation of RNA synthesis.