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Aromatic amino acid transaminases in rat brain
Author(s) -
Minatogawa Y.,
Noguchi T.,
Kido R.
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb00261.x
Subject(s) - transaminase , aromatic amino acids , tryptophan , phenylalanine , biochemistry , elevated transaminases , amino acid , aspartate transaminase , chemistry , enzyme , stereochemistry , biology , alkaline phosphatase
T he T ransamination of aromatic amino acids in brain is of interest due to its involvement in the biosynthesis of catechol and indole amines. Previous reports have established the presence of aromatic amino acid transaminases in brain (C anellakis and C ohen , 1962; A lbers , K oval and J akoby . 1962; H aavaldsen , 1962). It was subsequently reported that rat brain extracts contain at least three aromatic amino acid transaminases (Transaminase‐I, II and III) (F osnum , H aavaldsen and T angen , 1964; T angen , F owum and H aavaldsen , 1965: F ohwum and L arsen , 1965): Transaminase‐I had a high affinity for DOPA, Transaminase‐II an affinity for phenylalanine and tyrosine, and Transaminase‐III an affinity for tryptophan and 5‐HTP. The preferred aminoacceptor of these enzymes was 2‐oxoglutarate or oxaloacetate. The present paper describes the aromatic amino acid transaminases in an extract of rat brain, which differ from the three transaminases described by T angen et al. (1965).