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POLYAMINE TURNOVER IN DIFFERENT REGIONS OF RAT BRAIN 1
Author(s) -
Shaskan E. G.,
Snyder S. H.
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb00257.x
Subject(s) - putrescine , spermidine , spermine , pons , polyamine , cerebellum , striatum , endocrinology , medicine , chemistry , midbrain , biology , biochemistry , dopamine , central nervous system , enzyme
The dynamics of the formation and disappearance of polyamines in rat brain have been examined after intraventricular administration of a tracer dose of [ 3 H]putrescine. After 2 days [ 3 H]putrescine was no longer detectable in any brain region examined. [ 3 H] Spermidine and [ 3 H] spermine were formed in all brain areas. In the midbrain, hypothalamus and cerebellum (regions which manifested the greatest initial accumulation of tritium) the specific radioactivity of spermidine declined with a half‐life of 16‐19 days. However, in areas with a low initial accumulation of tritium (the medulla‐pons, internal capsule, cerebral cortex and corpus striatum) the specific radioactivity of spermidine changed very little between 2 and 19 days after the putrescine administration. Levels of [ 3 H]spermine increased continuously in all brain areas for a 14‐day period after the putrescine injection.