Premium
EVIDENCE FOR DEGENERATION OF SYMPATHETIC NERVE TERMINALS CAUSED BY THE ORTHO‐ AND PARA‐QUINONES OF 6‐HYDROXYDOPAMINE
Author(s) -
Heikkila R. E.,
Mytilineou C.,
Cócté L.,
Cohen G.
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb00246.x
Subject(s) - hydroxydopamine , adrenergic , sympathectomy , chemistry , norepinephrine , medicine , endocrinology , endogeny , sympathetic nerve , free nerve ending , biology , dopamine , blood pressure , receptor , dopaminergic
6‐Hydroxydopamine and its corresponding ortho ‐ and para ‐quinones were injected intraperitoneally into male Swiss‐Webster mice. Measurements made 72 h after injection showed that all three compounds caused a decrease in the uptake of [ 3 H]norepinephrine into slices of mouse heart tissue in vitro , a decrease in the endogenous content of heart norepine‐phrine, and a disappearance of the adrenergic nerve plexus of the mouse iris as viewed by fluorescence histochemistry. These data suggest that both the ortho ‐ and para ‐quinones of 6‐hydroxydopamine are capable of producing a chemical sympathectomy similar to that caused by 6‐hydroxydopamine.