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BIOSYNTHESIS OF SEROTONIN IN RAPHÉ NUCLEI OF RAT BRAIN: EFFECT OF p ‐CHLOROPHENYLALANINE 1
Author(s) -
Deguchi T.,
Sinha A. K.,
Barchas J. D.
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb00244.x
Subject(s) - serotonin , tryptophan , tryptophan hydroxylase , pargyline , medicine , endocrinology , chemistry , serotonergic , biology , amino acid , biochemistry , receptor
The activity of tryptophan hydroxylase (EC 1.99.1.4) in the region of the raphé nuclei of rat brain was higher than that of any other brain area. The content of serotonin and the rate of serotonin synthesis were also highest in the raphé nuclei. Following the administration of p ‐chlorophenylalanine the injection of tryptophan and pargyline increased the content of serotonin in the region of the raphé nuclei of rat brain. The results suggest that the raphé nuclei retained the capacity to hydroxyl‐late tryptophan to some extent after the injection of p ‐chlorophenylalanine.