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Turnover of brain adrenergic transmitters in Quaking mice
Author(s) -
Kempf E.,
Greilsamer J.,
Mack G.,
Mandel P.
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb00096.x
Subject(s) - endocrinology , dopamine , medicine , serotonin , norepinephrine , dopaminergic , metabolism , monoamine neurotransmitter , neurotransmitter , adrenergic , monoaminergic , biology , neuroscience , central nervous system , receptor
Q uaking mice, neurological mutants of the C57 BL/6J strain have a markedly deficient myelination of the CNS(S idman , D ickie and A ppel , 1964). Many studies have been carried out on their lipids (J acque , H arpin and B aumann , 1969; N eskovic , N ussbaum and M andel , 1969, 1970; K urihara , N ussbaum and M andel , 1970; S arlieve , N eskovic and M andel , 1971; S ingh , S pritz and G eyer , 1971) for this reason, but little attention has been paid to other aspects of their aminergic transmitters metabolism. During the course of our work, T illement , D ebarle , S imon and B oissier (1970) reported on the transmitter levels in Quaking mice. The reasons for thinking that the monoamine metabolism of these mice might be altered are as follows. The trembling might be associated with a change in the activity and therefore metabolism of dopaminergic structures. Chronic stress due to permanent tremor might induce changes in norepinephrine metabolism. Since there are changes in the sleep patterns of Quaking mice (V alatx and J ouvet , 1971), there might be changes in brain serotonin metabolism. This study of the turnover of norepinephrine, dopamine and serotonin in the whole brains of control and Quaking mice is the preliminary to detailed examination of the turnover of the transmitters in well‐defined brain regions.