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GLYCINE DECARBOXYLATION IN THE CENTRAL NERVOUS SYSTEM
Author(s) -
Uhr Marie Louise
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb00071.x
Subject(s) - glycine , decarboxylation , serine hydroxymethyltransferase , glycine cleavage system , central nervous system , pons , biochemistry , mitochondrion , nad+ kinase , chemistry , spinal cord , medulla , biology , dehydrogenase , amino acid , endocrinology , enzyme , anatomy , neuroscience , catalysis
— The regional and subcellular distribution of the glycine decarboxylation which occurs in the presence of tetrahydrofolate, NAD and pyridoxal phosphate, has been measured in CNS tissue of cat, sheep and rat. The activity appeared similar to that of liver. It was located within mitochondria, and distributed regionally and subcellularly in the same manner as succinate dehydrogenase, a mitochondrial marker. Activity was low in pons, medulla and spinal cord, and was not affected by a number of drugs, some of which excite and some of which depress the activity of the CNS. All evidence suggests that glycine decarboxylation plays no direct role in glycine inhibitory transmission.