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COMPOSITION OF MYELIN LIPIDS AND SYNTHESIS OF 3‐KETODIHYDROSPHINGOSINE IN THE VITAMIN B 6 ‐DEFICIENT DEVELOPING RAT 1
Author(s) -
Kurtz D. J.,
Kanfer J. N.
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb00066.x
Subject(s) - myelin , enzyme , vitamin , polyunsaturated fatty acid , biochemistry , cofactor , incubation , composition (language) , chemistry , biosynthesis , in vitro , biology , medicine , endocrinology , central nervous system , fatty acid , linguistics , philosophy
— Recoverable myelin in 20‐day‐old, Vitamin B 6 ‐deficient rats was reduced from that in control animals. The composition of myelin lipids from deficient animals was nearly identical to that for controls except for a striking reduction in phospholipids polyunsaturated fatty acids. Enzymatic synthesis in vitro of 3‐ketodihydrosphingosine was impaired in the deficient animals; addition of the vitamin Bs cofactor to these incubation mixtures restored activity of the condensing enzyme to control levels.