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Low molecular weight constituents of cerebrospinal fluid: N ‐benzoylglycine (hippuric acid)
Author(s) -
Couch Margaret W.,
Greer M.,
Scott K. N.,
Williams C. M.
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb00050.x
Subject(s) - hippuric acid , chromatography , chemistry , cerebrospinal fluid , mass spectrometry , gas chromatography–mass spectrometry , chemical ionization , gas chromatography , chemical constituents , organic chemistry , urine , ionization , biochemistry , pathology , medicine , ion
W hen examined by gas chromatography, methylated acid extracts of cerebrospinal fluid (CSF) contain large numbers (20–40) of constituents ranging in concentration from about 1 to 30 μg/ml. We have recently undertaken the identification of these constituents by the use of chemical ionization mass spectrometry and electron impact mass spectrometry as primary tools. In this paper we report the identification in CSF of N ‐benzoylglycine (hippuric acid), an acid not hitherto reported in CSF.