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INTERRELATIONSHIPS BETWEEN POLYAMINES AND NUCLEIC ACIDS. CHANGES OF POLYAMINE AND NUCLEIC ACID CONCENTRATIONS IN THE GROWING FISH BRAIN ( SALMO IRIDEUS GIBB. )
Author(s) -
Seiler N.,
Lamberty Ursula
Publication year - 1973
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1973.tb00031.x
Subject(s) - spermidine , spermine , putrescine , polyamine , nucleic acid , rna , salmo , biochemistry , dna , biology , cell growth , fish <actinopterygii> , chemistry , fishery , enzyme , gene
— In contrast to mouse brain, the content of putrescine in fish brain considerably exceeds that of spermine and spermidine. While we observed constant protein, RNA and spermidine concentrations in fish brains of weights between 60 and 800 mg, DNA and spermine concentrations diminished with increasing brain weight, the content of spermine per cell being constant throughout life. It can be concluded from our results that growth of fish brain results both from cell enlargement and cell proliferation. The concomitant changes of spermine and DNA concentrations in the growing fish brain are the first example of a direct quantitative relationship between these cell constituents and provides evidence on their possible functional relationship in the cell nucleus.