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ENZYME HISTOCHEMISTRY OF THE RAT HYPOTHALAMUS DURING EARLY DEVELOPMENT
Author(s) -
Robinson N.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb05101.x
Subject(s) - monoamine oxidase , hypothalamus , enzyme , thiamine pyrophosphate , acid phosphatase , endocrinology , medicine , biology , succinate dehydrogenase , atpase , lactate dehydrogenase , metabolism , biochemistry , chemistry , cofactor
—The distribution, localization and changes in intensity of enzymes in major metabolic pathways of brain metabolism during the first 16 days postnatal life of the rat anterior hypothalamus are reported. Thiamine pyrophosphatase, acid phosphatase and 5′‐nucleotidase showed rapid increases in activity between 0 and 5 days whilst AChE, Mg 2+ –ATPase and monoamine oxidase exhibited little or no activity before 3 days. Most enzymes showed a moderate intensity at 16 days in all nuclei whilst for some enzymes of phosphate metabolism the reaction was strong. The precocity of some enzymes particularly monoamine oxidase, lactate dehydrogenase and NADH 2 ‐diaphorase seen in other regions at birth, was not apparent in hypothalamic nuclei. Comparisons are made with other regions of the brain and the findings discussed in relation to function.