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DIFFERENTIAL DETERMINATION OF HEXOSAMINIDASES A AND B AND OF TWO FORMS OF β‐GALACTOSIDASE, IN THE LAYERS OF THE HUMAN CEREBELLUM 1
Author(s) -
Hirsch Hilde E.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb05095.x
Subject(s) - cerebellum , hexosaminidase , isozyme , biochemistry , chemistry , granular layer , enzyme , biology , biophysics , endocrinology
—In order to determine whether or not various histological elements of the nervous system may differ in their relative content of hexosaminidase A and B (O'B rien , O kada , C hen and F illerup , 1970) and in the‘acid’and‘neutral’forms of β‐galactosidase (Ho and O'B rien , 1971), these isoenzymes were determined separately in the layers of human cerebellum. The proportion of the heat‐stable hexosaminidase B was greater in the granular layer than in the molecular layer or underlying white matter. The activity of the‘neutral’form of β‐galactosidase was very low compared to the‘acid’type, but its distribution was similar.