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ZINC IN MATURING RAT BRAIN: HIPPOCAMPAL CONCENTRATION AND LOCALIZATION 1
Author(s) -
Crawford I. L.,
Connor J. D.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb05088.x
Subject(s) - hippocampal formation , zinc , granule cell , granule (geology) , hippocampus , chemistry , cell fractionation , biophysics , biology , microbiology and biotechnology , neuroscience , medicine , biochemistry , dentate gyrus , enzyme , paleontology , organic chemistry
—Alterations in the localization and concentration of zinc in the hippocampus and in other regions of rat brain were studied during postnatal maturation. Histochemical observations indicated increasing levels of zinc in the hippocampal mossy fibre layer at about 20 days of age. Between 18 and 22 days, hippocampal levels of zinc increased by 35 per cent to reach adult levels (121 ng/mg of protein). After subcellular fractionation, more than one‐half of the hippocampal zinc was found in the first pellet (P 1 ; 1085 g – 10 min), where large boutons would be expected. Autoradiographic evidence, revealing the sequential location of positron tracks first in the granular cell layer and later in the mossy fibre layer, raises the possibility of axoplasmic transport of zinc from granule cell perikarya to their terminal boutons. Our data suggest that zinc may be involved in the maturation and function of the mossy fibre pathway.