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EVIDENCE THAT METHADONE BLOCKS DOPAMINE RECEPTORS IN THE BRAIN
Author(s) -
Sasame H. A.,
PerezCruet J.,
Chiara G.,
Tagliamonte A.,
Tagliamonte P.,
Gessa G. L.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb01484.x
Subject(s) - apomorphine , homovanillic acid , methadone , dopamine , catalepsy , pharmacology , dopamine receptor , chemistry , receptor , medicine , endocrinology , dopaminergic , haloperidol , serotonin
— This study has shown that methadone shares with phenothiazine and butyro‐phenoneneuroleptics several pharmacological and biochemical actions:thus, D,L‐methadone causes catalepsy and hypothermia, blocks apomorphine‐induced gnawing, increases brain homovanillic acid levels and stimulates brain dopamine synthesis. The dextro isomer of methadone is inactive. α‐Methyl‐tyrosine potentiates and apomorphine reverses methadone‐induced catalepsy. The data suggest that methadone, like butyrophenone and phenothiazine neuroleptics, blocks dopamine receptors in brain.