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THE ABSENCE OF ‘SURPLUS’ ACETYLCHOLINE FORMATION IN PRISMS PREPARED FROM RAT CEREBRAL CORTEX
Author(s) -
Bourdois P. S.,
Szerb J. C.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb01439.x
Subject(s) - acetylcholine , cholinesterase , incubation , cerebral cortex , chemistry , potassium , cortex (anatomy) , reuptake , endocrinology , medicine , biophysics , biochemistry , biology , neuroscience , serotonin , receptor , organic chemistry
— Prisms of rat cerebral cortex incubated without cholinesterase inhibitor showed an increase in ACh content during the first hour of incubation. The effects of adding cholinesterase inhibitors during the second hour depended on the potassium concentration. At 6 mM‐K + there was only a small rise in ACh but when K + was raised to 25 mM a large increase in ACh content was observed. It is proposed that the increase in ACh is due to the reuptake of released ACh.