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TYROSINE HYDROXYLASE IN RAT BRAIN: DEVELOPMENTAL CHARACTERISTICS
Author(s) -
Coyle J. T.,
Axelrod J.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb01431.x
Subject(s) - tyrosine hydroxylase , catecholaminergic , tyrosine , tyrosine 3 monooxygenase , endocrinology , dopamine , medicine , catecholaminergic cell groups , specific activity , enzyme , tryptophan hydroxylase , biology , catecholamine , norepinephrine , chemistry , biochemistry , serotonin , receptor , serotonergic
— The development of tyrosine hydroxylase (tyrosine 3‐hydroxylase, EC 1.14.3.a) activity has been examined in whole rat brain and in various regions and subcellular fractions thereof. The specific activity of tyrosine hydroxylase increased almost 15‐fold from 15 days of gestation to adulthood. With maturation, those regions of the brain that contain only terminals of the catecholaminergic neurons showed the greatest increases in enzyme activity. There was a shift in the subcellular distribution of tyrosine hydroxylase from the soluble fraction in the fetal brain to the synaptosomal fraction in the adult brain. Tyrosine hydroxylase, dopamine hydroxylase (EC 1.14.2.1) and the specific uptake mechanism for norepinephrine appear to develop in a coordinated fashion.