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THE GLUTAMATE AND GLUTAMINE CONTENT OF RAT BRAIN AFTER PORTOCAVAL ANASTOMOSIS
Author(s) -
Williams A. H.,
Kyu Ma Hta,
Fenton J. C. B.,
Cavanagh J. B.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb01427.x
Subject(s) - glutamine , glutamate receptor , ammonium , anastomosis , metabolism , glutamine synthetase , medicine , endocrinology , compartment (ship) , chemistry , portacaval anastomosis , biochemistry , biology , surgery , amino acid , oceanography , receptor , cirrhosis , organic chemistry , portal hypertension , geology
— Rats have been subjected to portocaval anastomosis and the ammonium ion in plasma and the glutamate and glutamine levels in plasma, red cells and brain have been estimated up to 6 weeks after operation. The glutamine, but not the glutamate, levels in brain were consistently raised, being about 2.5 times greater than normal and the level can be correlated with the level of plasma ammonium ion. Consideration is given to the possibility that the glutamine may be in the greatly enlarged neuroglial compartment in this abnormal metabolic state.