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ASPARAGINASE IN PERIPHERAL NERVES OF THE GUINEA PIG IN WALLERIAN DEGENERATION AND EXPERIMENTAL ALLERGIC NEURITIS
Author(s) -
Varsik P.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb01396.x
Subject(s) - wallerian degeneration , neuritis , peripheral , guinea pig , medicine , butyrylcholinesterase , endocrinology , anesthesia , enzyme , immunology , acetylcholinesterase , pathology , chemistry , aché , surgery , biochemistry
— Asparaginase ( 1 ‐asparagine amidohydrolase EC 3 , 5.1.1.) activity in peripheral nerves in Wallerian degeneration and in experimental allergic neuritis was studied in the guinea pig. After mechanical damage to the sciatic nerve, asparaginase enzymic activity increased markedly in the regenerating (central) stump at the end of the first week, followed by a decrease in activity almost to control values in the course of 4 weeks, whereas in the degenerating (peripheral) stump, after an increase in activity at the end of the first week the enzyme activity continued to increase reaching 250 per cent of the control values at the end of the fourth week. An increase in asparaginase activity was also observed in experimental allergic neuritis.