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GANGLIOSIDES OF THE OPTIC PATHWAY: BIOSYNTHESIS AND BIODEGRADATION STUDIED IN VIVO
Author(s) -
Holm M.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb01379.x
Subject(s) - ganglioside , glucosamine , optic nerve , ethanolamine , chemistry , in vivo , biochemistry , biosynthesis , optic tract , choline , phosphocholine , retina , biology , anatomy , membrane , retinal , enzyme , microbiology and biotechnology , neuroscience , phospholipid , phosphatidylcholine
— Rabbits were given an intraocular injection of [ 3 H]acetate and [1‐ 14 C]glucosamine. The two precursors were incorporated into the gangliosides, whose activities were measured in the retina, optic nerve, optic tract and lateral geniculate body. The radioactivities of cerebrosides and ethanolamine and choline phosphoglycerides were also determined. Gangliosides were labelled in all parts of the optic pathway, from both acetate and glucosamine. The precursors seemed to be distributed along the entire pathway shortly after injection. They were not transported with the blood and no ganglioside transport could be shown.