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CATECHOLAMINE INDUCED INCREASE OF CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE IN RAT BRAIN IN VIVO
Author(s) -
Burkard W. P.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb01320.x
Subject(s) - endocrinology , medicine , adenosine , epinephrine , catecholamine , in vivo , dopamine , norepinephrine , cyclic adenosine monophosphate , chemistry , adenosine monophosphate , biology , receptor , microbiology and biotechnology
— Four catecholamines injected into the cerebral ventricles increased the content of cyclic adenosine 3′,5′‐monophosphate (cAMP) in vivo in the whole brain of rats. The highest rise (2.6‐fold) was measured 2 min after an injection of 100 μg epinephrine. Isoproterenol and norepinephrine were less active and dopamine hardly increased the cAMP level. These results are compatible with the view that physiological actions of catecholamines in the nervous system may be mediated by an increase of CAMP.