Premium
PHOSPHOCHOLINE DIGLYCERIDE TRANSFERASE ACTIVITY DURING DEVELOPMENT OF THE CHICKEN BRAIN
Author(s) -
Freysz L.,
Lastennet A.,
Mandel P.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb01318.x
Subject(s) - phosphocholine , hatching , transferase , diglyceride , choline , endocrinology , medicine , enzyme , biology , embryo , chemistry , phosphatidylcholine , biochemistry , microbiology and biotechnology , phospholipid , zoology , membrane
Abstract— The activity of chicken brain phosphocholine diglyceride transferase was followed during pre‐ and postnatal development. The specific activity of this enzyme increases from the 10th day of embryonic life, reaches a maximum at hatching and decreases thereafter. Total brain activity increases in parallel with the increase of brain lecithins. The apparent K m of the enzyme for CDP choline is 1.5 × 10 ‐4 m before the 10th day of embryonic life, 2.5 × 10 ‐5 m between the 13th day of the embryo and the 10th day after hatching, and finally 1.3 × 10 ‐4 m after the 38th day of postnatal life. These data suggest the existence of isoenzymes, one of which appears at the beginning of myelination.