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CHANGES IN BLOOD FLOW IN THE COMPONENT STRUCTURES OF THE DOG BRAIN DURING POSTNATAL MATURATION
Author(s) -
Kennedy C.,
Grave G. D.,
Jehle Jane W.,
Sokoloff L.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb01296.x
Subject(s) - ontogeny , biology , blood flow , maturity (psychological) , period (music) , cerebral blood flow , physiology , brain development , perfusion , medicine , endocrinology , anatomy , neuroscience , psychology , developmental psychology , physics , acoustics
— Blood flow was measured quantitatively in 35 structures of the brains of dogs of various ages from birth to maturity. In general, values were low at birth and rose to maximal levels between 3 and 7 weeks of postnatal age; declines from the peak levels then followed until values characteristic of maturity were attained by 13 weeks of postnatal age. From relatively uniform perfusion rates throughout the brain at birth there gradually emerged a marked heterogeneity, in parallel with the structural and functional maturation and differentiation known to occur in the brain during this period of life. Our observations may reflect the summation of the changes in energy demands associated on the one hand with biosynthetic processes essential for growth and development and with the support for progressively increasing functional activities on the other.