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STUDIES ON GANGLIOSIDES OF GOLDFISH BRAIN 1
Author(s) -
MCCluer R. H.,
Agranoff B. W.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb01284.x
Subject(s) - puromycin , galactose , brain chemistry , biochemistry , chemistry , thin layer chromatography , chromatography , biology , endocrinology , protein biosynthesis
— Purified gangliosides from goldfish brain have been separated on thin layer chromatography. Incorporation of radioactivity into gangliosides from intracranially‐ injected [ 3 H]galactose was not affected by concentrations of puromycin (170 μg intra‐ cranially) known to exert behavioural effects. Puromycin (500 μg intracranially) inhibited the incorporation of radiolabelled galactose into infant rat brain gangliosides, a result which confirms a previous report in the literature.