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AMINO ACIDS AS PUTATIVE TRANSMITTERS: FAILURE TO BIND TO SYNAPTIC VESICLES OF GUINEA PIG CEREBRAL CORTEX 1
Author(s) -
Rassin D. K.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb01263.x
Subject(s) - synaptic vesicle , amino acid , acetylcholine , guinea pig , cerebral cortex , biochemistry , biology , chemistry , depressant , vesicle , cortex (anatomy) , neurotransmitter , biophysics , neuroscience , central nervous system , pharmacology , endocrinology , membrane
— The levels of free amino acids in subcellular fractions of guinea pig cerebral cortex have been determined. Putative transmitter amino acids are not bound to synaptic vesicles in a manner analogous to acetylcholine, as shown by the failure of hypo‐osmotic shock to cause a specific release of the excitant and depressant amino acids.