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THE 4‐ O ‐METHYL METABOLITES OF CATECHOLAMINES IN MAN: CHROMATOGRAPHIC IDENTIFICATION OF 3‐HYDROXY,4‐METHOXYPHENYLACETIC ACID (HOMO‐ISO‐VANILLIC ACID) IN CEREBROSPINAL FLUID
Author(s) -
Mathieu P.,
Revol L.,
Trouillas P.
Publication year - 1972
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1972.tb01255.x
Subject(s) - homovanillic acid , vanillic acid , chromatography , chemistry , cerebrospinal fluid , dopamine , organic chemistry , biochemistry , biology , endocrinology , serotonin , receptor , neuroscience
— The isomeric phenolic acids, homovanillic acid (4‐hydroxy,3‐methoxyphenylacetic acid) and homo‐iso‐vanillic acid (3‐hydroxy,4‐methoxyphenylacetic acid), were separated and identified by means of paper chromatography of their azo‐derivatives with diazotized para‐nitroaniline. Using this chromatographic procedure, homo‐iso‐vaniliic acid was identified in several samples of human cerebrospinal fluid, an observation which suggests that dopamine may be partly metabolized in brain, with the production of 4‐methoxy derivatives.