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THE COMPARATIVE EFFECTS OF VARIOUS HYDRA‐ZIDES ON γ‐AMINOBUTYRIC ACID AND ITS METABOLISM
Author(s) -
Wood J. D.,
Abrahams Dawne E.
Publication year - 1971
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1971.tb12031.x
Subject(s) - aminobutyric acid , metabolism , endocrinology , medicine , biology , chemistry , biochemistry , receptor
— The administration of different hydrazides to chicks (20‐23 days post‐hatching) in amounts giving similar latent periods before the onset of seizures produced (i) similar rates of decrease in content of cerebral GABA, (ii) considerable but dissimilar inhibitions of cerebral GAD activity, (iii) slight inhibitions of cerebral GABA‐T activity. The results support the view that low GABA levels were involved in. the etiology of the seizures but seemed to rule out the possibility that a reduced turnover of GABA was responsible for the occurrence of the convulsions.