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POTENTIATION OF AMP‐AMINOHYDROLASE ACTIVITY OF BRAIN MITOCHONDRIA BY HEXOKINASE
Author(s) -
Buniatian H. Ch.,
Haroutunian A. V.
Publication year - 1971
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1971.tb12016.x
Subject(s) - hexokinase , mitochondrion , biochemistry , enzyme , yeast , chemistry , biology , glycolysis
— The addition of hexokinase (yeast and brain) to mitochondrial fractions of brain (rat) resulted in a considerable increase of formation of ammonia from AMP. The mechanisms underlying the activation of AMP‐aminohydrolase of brain mitochondria by ATP and hexokinase are quite different. In the activation of AMP‐aminohydrolase by hexokinase the SH‐groups of both enzymes particularly of the latter are of importance. Brain mitochondria contain low‐molecular dialysable substances of unknown nature which are necessary for the interaction of both enzymes.